Natural IgM switches the function of LPS activated murine bone marrow dendritic cells (BMDC) to a “regulatory” DC that suppresses innate inflammation()

We have previously shown that polyclonal natural IgM protects mice from renal IRI by inhibiting the reperfusion inflammatory response. We hypothesized that a potential mechanism involved IgM modulation of dendritic cells as we observed high IgM binding to splenic DC. To test this hypothesis, we pre-...

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Udgivet i:J Immunol
Main Authors: Lobo, Peter I, Schlegel, Kailo H., Bajwa, Amandeep, Huang, Liping, Kurmaeva, Elvira, Wang, Binru, Ye, Hong, Tedder, Thomas F., Kinsey, Gilbert R., Okusa, Mark D.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4655187/
https://ncbi.nlm.nih.gov/pubmed/26519533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500052
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