The TGF-β signalling negative regulator PICK1 represses prostate cancer metastasis to bone

BACKGROUD: Constitutive activation of TGF-β signalling is a well-recognised mechanism in bone metastasis of prostate cancer (PCa). Protein Interacting with PRKCA 1 (PICK1) is a critical negative regulator of the TGF-β pathway. However, the clinical significance and biological role of PICK1 in PCa bo...

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Bibliografske podrobnosti
izdano v:Br J Cancer
Main Authors: Dai, Yuhu, Ren, Dong, Yang, Qing, Cui, Yanmei, Guo, Wei, Lai, Yingrong, Du, Hong, Lin, Chuyong, Li, Jun, Song, Libing, Peng, Xinsheng
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
Teme:
Molecular Diagnostics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572169/
https://ncbi.nlm.nih.gov/pubmed/28697177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.212
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