Loss of C-5 Sterol Desaturase Activity Results in Increased Resistance to Azole and Echinocandin Antifungals in a Clinical Isolate of Candida parapsilosis

Among emerging non-albicans Candida species, Candida parapsilosis is of particular concern as a cause of nosocomial bloodstream infections in neonatal and intensive care unit patients. While fluconazole and echinocandins are considered effective treatments for such infections, recent reports of fluc...

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Udgivet i:Antimicrob Agents Chemother
Main Authors: Rybak, Jeffrey M., Dickens, C. Michael, Parker, Josie E., Caudle, Kelly E., Manigaba, Kayihura, Whaley, Sarah G., Nishimoto, Andrew T., Luna-Tapia, Arturo, Roy, Sujoy, Zhang, Qing, Barker, Katherine S., Palmer, Glen E., Sutter, Thomas R., Homayouni, Ramin, Wiederhold, Nathan P., Kelly, Steven L., Rogers, P. David
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5571332/
https://ncbi.nlm.nih.gov/pubmed/28630186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00651-17
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