Cooperation between Strain-Specific and Broadly Neutralizing Responses Limited Viral Escape and Prolonged the Exposure of the Broadly Neutralizing Epitope

V3-glycan-targeting broadly neutralizing antibodies (bNAbs) are a focus of HIV-1 vaccine development. Understanding the viral dynamics that stimulate the development of these antibodies can provide insights for immunogen design. We used a deep-sequencing approach, together with neutralization phenot...

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Vydáno v:J Virol
Hlavní autoři: Anthony, Colin, York, Talita, Bekker, Valerie, Matten, David, Selhorst, Philippe, Ferreria, Roux-Cil, Garrett, Nigel J., Karim, Salim S. Abdool, Morris, Lynn, Wood, Natasha T., Moore, Penny L., Williamson, Carolyn
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
Genetic Diversity and Evolution
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5571269/
https://ncbi.nlm.nih.gov/pubmed/28679760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00828-17
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