Partially Uncleaved Alphavirus Replicase Forms Spherule Structures in the Presence and Absence of RNA Template

Alphaviruses are positive-strand RNA viruses expressing their replicase as a polyprotein, P1234, which is cleaved to four final products, nonstructural proteins nsP1 to nsP4. The replicase proteins together with viral RNA and host factors form membrane invaginations termed spherules, which act as th...

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Bibliographic Details
Published in:J Virol
Main Authors: Hellström, Kirsi, Kallio, Katri, Utt, Age, Quirin, Tania, Jokitalo, Eija, Merits, Andres, Ahola, Tero
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5571266/
https://ncbi.nlm.nih.gov/pubmed/28701392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00787-17
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