Enfuvirtide (T20)-Based Lipopeptide Is a Potent HIV-1 Cell Fusion Inhibitor: Implications for Viral Entry and Inhibition

The peptide drug enfuvirtide (T20) is the only viral fusion inhibitor used in combination therapy for HIV-1 infection, but it has relatively low antiviral activity and easily induces drug resistance. Emerging studies demonstrate that lipopeptide-based fusion inhibitors, such as LP-11 and LP-19, whic...

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Vydáno v:J Virol
Hlavní autoři: Ding, Xiaohui, Zhang, Xiujuan, Chong, Huihui, Zhu, Yuanmei, Wei, Huamian, Wu, Xiyuan, He, Jinsheng, Wang, Xinquan, He, Yuxian
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5571253/
https://ncbi.nlm.nih.gov/pubmed/28659478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00831-17
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