Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance

Mammalian biology adapts to physical activity but the molecular mechanisms sensing the activity remain enigmatic. Recent studies have revealed how Piezo1 protein senses mechanical force to enable vascular development. Here, we address Piezo1 in adult endothelium, the major control site in physical a...

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Publicat a:Nat Commun
Autors principals: Rode, Baptiste, Shi, Jian, Endesh, Naima, Drinkhill, Mark J., Webster, Peter J., Lotteau, Sabine J., Bailey, Marc A., Yuldasheva, Nadira Y., Ludlow, Melanie J., Cubbon, Richard M., Li, Jing, Futers, T. Simon, Morley, Lara, Gaunt, Hannah J., Marszalek, Katarzyna, Viswambharan, Hema, Cuthbertson, Kevin, Baxter, Paul D., Foster, Richard, Sukumar, Piruthivi, Weightman, Andrew, Calaghan, Sarah C., Wheatcroft, Stephen B., Kearney, Mark T., Beech, David J.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5571199/
https://ncbi.nlm.nih.gov/pubmed/28839146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00429-3
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