Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms

Second mitochondrial activator of caspase (Smac)-mimetic compounds and oncolytic viruses were developed to kill cancer cells directly. However, Smac-mimetic compound and oncolytic virus therapies also modulate host immune responses in ways we hypothesized would complement one another in promoting an...

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發表在:Nat Commun
Main Authors: Kim, Dae-Sun, Dastidar, Himika, Zhang, Chunfen, Zemp, Franz J., Lau, Keith, Ernst, Matthias, Rakic, Andrea, Sikdar, Saif, Rajwani, Jahanara, Naumenko, Victor, Balce, Dale R., Ewanchuk, Ben W., Tailor, Pankaj, Yates, Robin M., Jenne, Craig, Gafuik, Chris, Mahoney, Douglas J.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570934/
https://ncbi.nlm.nih.gov/pubmed/28839138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00324-x
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