Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms

Second mitochondrial activator of caspase (Smac)-mimetic compounds and oncolytic viruses were developed to kill cancer cells directly. However, Smac-mimetic compound and oncolytic virus therapies also modulate host immune responses in ways we hypothesized would complement one another in promoting an...

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Publicat a:Nat Commun
Autors principals: Kim, Dae-Sun, Dastidar, Himika, Zhang, Chunfen, Zemp, Franz J., Lau, Keith, Ernst, Matthias, Rakic, Andrea, Sikdar, Saif, Rajwani, Jahanara, Naumenko, Victor, Balce, Dale R., Ewanchuk, Ben W., Tailor, Pankaj, Yates, Robin M., Jenne, Craig, Gafuik, Chris, Mahoney, Douglas J.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570934/
https://ncbi.nlm.nih.gov/pubmed/28839138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00324-x
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