Somatic and germline TP53 alterations in second malignant neoplasms from pediatric cancer survivors

PURPOSE: Second malignant neoplasms (SMNs) are severe late complications that occur in pediatric cancer survivors exposed to radiotherapy and other genotoxic treatments. To characterize the mutational landscape of treatment-induced sarcomas and to identify candidate SMN-predisposing variants we anal...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Sherborne, Amy L., Lavergne, Vincent, Yu, Katharine, Lee, Leah, Davidson, Philip R., Mazor, Tali, Smirnoff, Ivan, Horvai, Andrew, Loh, Mignon, DuBois, Steven G., Goldsby, Robert E., Neglia, Joseph, Hammond, Sue, Robison, Leslie L., Wustrack, Rosanna, Costello, Joseph, Nakamura, Alice O., Shannon, Kevin, Bhatia, Smita, Nakamura, Jean L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570538/
https://ncbi.nlm.nih.gov/pubmed/27683180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-0610
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