Rates and equilibrium constants of the ligand-induced conformational transition of an HCN ion channel protein domain determined by DEER spectroscopy

Ligand binding can induce significant conformational changes in proteins. The mechanism of this process couples equilibria associated with the ligand binding event and the conformational change. Here we show that by combining the application of W-band double electron-electron resonance (DEER) spectr...

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Bibliographic Details
Published in:Phys Chem Chem Phys
Main Authors: Collauto, Alberto, DeBerg, Hannah A., Kaufmann, Royi, Zagotta, William N., Stoll, Stefan, Goldfarb, Daniella
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570514/
https://ncbi.nlm.nih.gov/pubmed/28569901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7cp01925d
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