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Allosteric conformational change of a cyclic nucleotide-gated ion channel revealed by DEER spectroscopy
Cyclic nucleotide-gated (CNG) ion channels are essential components of mammalian visual and olfactory signal transduction. CNG channels open upon direct binding of cyclic nucleotides (cAMP and/or cGMP), but the allosteric mechanism by which this occurs is incompletely understood. Here, we employed d...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7245078/ https://ncbi.nlm.nih.gov/pubmed/32358188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1916375117 |
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