Structural analysis of P. falciparum KAHRP and PfEMP1 complexes with host erythrocyte spectrin suggests a model for cytoadherent knob protrusions

Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) and Knob-associated Histidine-rich Protein (KAHRP) are directly linked to malaria pathology. PfEMP1 and KAHRP cluster on protrusions (knobs) on the P. falciparum-infected erythrocyte surface and enable pathogenic cytoadherence of infected...

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Gepubliceerd in:PLoS Pathog
Hoofdauteurs: Cutts, Erin E., Laasch, Niklas, Reiter, Dirk M., Trenker, Raphael, Slater, Leanne M., Stansfeld, Phillip J., Vakonakis, Ioannis
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2017
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570508/
https://ncbi.nlm.nih.gov/pubmed/28806784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006552
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