Complement C1s cleaves PfEMP1 at interdomain conserved sites inhibiting Plasmodium falciparum cytoadherence

Cytoadhesion of Plasmodium falciparum-infected erythrocytes (IEs) to the endothelial lining of blood vessels protects parasites from splenic destruction, but also leads to detrimental inflammation and vessel occlusion. Surface display of the P. falciparum erythrocyte membrane protein 1 (PfEMP1) adhe...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Azasi, Yvonne, Low, Leanne M., Just, Ashley N., Raghavan, Sai S. R., Wang, Christian W., Valenzuela-Leon, Paola, Rowe, J. Alexandra, Smith, Joseph D., Lavstsen, Thomas, Turner, Louise, Calvo, Eric, Miller, Louis H.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2021
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8179237/
https://ncbi.nlm.nih.gov/pubmed/34035177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2104166118
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