A ‘synthetic-sickness’ screen for senescence re-engagement targets in mutant cancer backgrounds

Senescence is a universal barrier to immortalisation and tumorigenesis. As such, interest in the use of senescence-induction in a therapeutic context has been gaining momentum in the past few years; however, senescence and immortalisation remain underserved areas for drug discovery owing to a lack o...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:PLoS Genet
Päätekijät: Cairney, Claire J., Godwin, Lauren S., Bilsland, Alan E., Burns, Sharon, Stevenson, Katrina H., McGarry, Lynn, Revie, John, Moore, Jon D., Wiggins, Ceri M., Collinson, Rebecca S., Mudd, Clare, Tsonou, Elpida, Sadaie, Mahito, Bennett, Dorothy C., Narita, Masashi, Torrance, Christopher J., Keith, W. Nicol
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2017
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570495/
https://ncbi.nlm.nih.gov/pubmed/28806777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006942
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