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A systems approach reveals distinct metabolic strategies among the NCI-60 cancer cell lines

The metabolic phenotype of cancer cells is reflected by the metabolites they consume and by the byproducts they release. Here, we use quantitative, extracellular metabolomic data of the NCI-60 panel and a novel computational method to generate 120 condition-specific cancer cell line metabolic models...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Aurich, Maike K., Fleming, Ronan M. T., Thiele, Ines
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570491/
https://ncbi.nlm.nih.gov/pubmed/28806730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005698
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