Epithelial calcineurin controls microbiota-dependent intestinal tumor development

Inflammation-associated pathways are active in intestinal epithelial cells (IECs) and contribute to the pathogenesis of colorectal cancer (CRC). Calcineurin, a phosphatase required for the activation of the nuclear factor of activated T cells (NFAT) family of transcription factors, shows increased e...

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Udgivet i:Nat Med
Main Authors: Peuker, Kenneth, Muff, Stefanie, Wang, Jun, Künzel, Sven, Bosse, Esther, Zeissig, Yvonne, Luzzi, Giuseppina, Basic, Marijana, Strigli, Anne, Ulbricht, Andrea, Kaser, Arthur, Arlt, Alexander, Chavakis, Triantafyllos, van den Brink, Gijs R, Schafmayer, Clemens, Egberts, Jan-Hendrik, Becker, Thomas, Bianchi, Marco E, Bleich, André, Röcken, Christoph, Hampe, Jochen, Schreiber, Stefan, Baines, John F, Blumberg, Richard S, Zeissig, Sebastian
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570457/
https://ncbi.nlm.nih.gov/pubmed/27043494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4072
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