VDAC1 is a molecular target in glioblastoma, with its depletion leading to reprogrammed metabolism and reversed oncogenic properties

BACKGROUND. Glioblastoma (GBM), an aggressive brain tumor with frequent relapses and a high mortality, still awaits an effective treatment. Like many cancers, GBM cells acquire oncogenic properties, including metabolic reprogramming, vital for growth. As such, tumor metabolism is an emerging avenue...

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Bibliographische Detailangaben
Veröffentlicht in:Neuro Oncol
Hauptverfasser: Arif, Tasleem, Krelin, Yakov, Nakdimon, Itay, Benharroch, Daniel, Paul, Avijit, Dadon-Klein, Daniela, Shoshan-Barmatz, Varda
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
Schlagworte:
Basic and Translational Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570220/
https://ncbi.nlm.nih.gov/pubmed/28339833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now297
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