Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells

Mobilization of retrotransposons to new genomic locations is a significant driver of mammalian genome evolution, but these mutagenic events can also cause genetic disorders. In humans, retrotransposon mobilization is mediated primarily by proteins encoded by LINE-1 (L1) retrotransposons, which mobil...

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Vydáno v:eLife
Hlavní autoři: MacLennan, Marie, García-Cañadas, Marta, Reichmann, Judith, Khazina, Elena, Wagner, Gabriele, Playfoot, Christopher J, Salvador-Palomeque, Carmen, Mann, Abigail R, Peressini, Paula, Sanchez, Laura, Dobie, Karen, Read, David, Hung, Chao-Chun, Eskeland, Ragnhild, Meehan, Richard R, Weichenrieder, Oliver, García-Pérez, Jose Luis, Adams, Ian R
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2017
Témata:
Developmental Biology and Stem Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570191/
https://ncbi.nlm.nih.gov/pubmed/28806172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.26152
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