Piwi interacts with chromatin at nuclear pores and promiscuously binds nuclear transcripts in Drosophila ovarian somatic cells

Piwi in a complex with Piwi-interacting RNAs (piRNAs) triggers transcriptional silencing of transposable elements (TEs) in Drosophila ovaries, thus ensuring genome stability. To do this, Piwi must scan the nascent transcripts of genes and TEs for complementarity to piRNAs. The mechanism of this scan...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Ilyin, Artem A., Ryazansky, Sergei S., Doronin, Semen A., Olenkina, Oxana M., Mikhaleva, Elena A., Yakushev, Evgeny Y., Abramov, Yuri A., Belyakin, Stepan N., Ivankin, Anton V., Pindyurin, Alexey V., Gvozdev, Vladimir A., Klenov, Mikhail S., Shevelyov, Yuri Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2017
Soggetti:
Gene regulation, Chromatin and Epigenetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570135/
https://ncbi.nlm.nih.gov/pubmed/28472469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx355
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