Cell-type-specific genome editing with a microRNA-responsive CRISPR–Cas9 switch

The CRISPR–Cas9 system is a powerful genome-editing tool useful in a variety of biotechnology and biomedical applications. Here we developed a synthetic RNA-based, microRNA (miRNA)-responsive CRISPR–Cas9 system (miR-Cas9 switch) in which the genome editing activity of Cas9 can be modulated through e...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Hirosawa, Moe, Fujita, Yoshihiko, Parr, Callum J. C., Hayashi, Karin, Kashida, Shunnichi, Hotta, Akitsu, Woltjen, Knut, Saito, Hirohide
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Methods Online
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570128/
https://ncbi.nlm.nih.gov/pubmed/28525578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx309
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