CRISPR-Cas3 induces broad and unidirectional genome editing in human cells

Although single-component Class 2 CRISPR systems, such as type II Cas9 or type V Cas12a (Cpf1), are widely used for genome editing in eukaryotic cells, the application of multi-component Class 1 CRISPR has been less developed. Here we demonstrate that type I-E CRISPR mediates distinct DNA cleavage a...

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Vydáno v:Nat Commun
Hlavní autoři: Morisaka, Hiroyuki, Yoshimi, Kazuto, Okuzaki, Yuya, Gee, Peter, Kunihiro, Yayoi, Sonpho, Ekasit, Xu, Huaigeng, Sasakawa, Noriko, Naito, Yuki, Nakada, Shinichiro, Yamamoto, Takashi, Sano, Shigetoshi, Hotta, Akitsu, Takeda, Junji, Mashimo, Tomoji
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6897959/
https://ncbi.nlm.nih.gov/pubmed/31811138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13226-x
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