Reversible phosphorylation--dephosphorylation determines the localization of rab4 during the cell cycle.

The ras-like GTP binding protein rab4 is the only known rab protein on endosomes that is phosphorylated during mitosis. Since a large fraction of rab4 accumulates in the cytosol in mitotic cells, we investigated the molecular mechanism controlling membrane association of rab4. We first show that hum...

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Enregistré dans:
Détails bibliographiques
Publié dans:EMBO J
Auteurs principaux: van der Sluijs, P, Hull, M, Huber, L A, Mâle, P, Goud, B, Mellman, I
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 1992
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC557012/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1425574/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1992.tb05538.x
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