Major hnRNP proteins act as general TDP-43 functional modifiers both in Drosophila and human neuronal cells

Nuclear factor TDP-43 is known to play an important role in several neurodegenerative pathologies. In general, TDP-43 is an abundant protein within the eukaryotic nucleus that binds to many coding and non-coding RNAs and influence their processing. Using Drosophila, we have performed a functional sc...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Appocher, Chiara, Mohagheghi, Fatemeh, Cappelli, Sara, Stuani, Cristiana, Romano, Maurizio, Feiguin, Fabian, Buratti, Emanuele
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
Schlagworte:
RNA
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570092/
https://ncbi.nlm.nih.gov/pubmed/28575377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx477
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