What limits affinity maturation of antibodies in Xenopus--the rate of somatic mutation or the ability to select mutants?

Although the Xenopus immunoglobulin heavy chain locus is structurally and functionally similar to mammalian IgH loci, Xenopus antibodies are limited in heterogeneity, and they mature only slightly in affinity during immune responses. During the antibody response of isogenic frogs to DNP-KLH, mu and...

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Bibliographische Detailangaben
Hauptverfasser: Wilson, M, Hsu, E, Marcuz, A, Courtet, M, Du Pasquier, L, Steinberg, C
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1992
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC557007/
https://ncbi.nlm.nih.gov/pubmed/1425571
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