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What limits affinity maturation of antibodies in Xenopus--the rate of somatic mutation or the ability to select mutants?

Although the Xenopus immunoglobulin heavy chain locus is structurally and functionally similar to mammalian IgH loci, Xenopus antibodies are limited in heterogeneity, and they mature only slightly in affinity during immune responses. During the antibody response of isogenic frogs to DNP-KLH, mu and...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Wilson, M, Hsu, E, Marcuz, A, Courtet, M, Du Pasquier, L, Steinberg, C
פורמט: Artigo
שפה:Inglês
יצא לאור: 1992
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC557007/
https://ncbi.nlm.nih.gov/pubmed/1425571
תגים: הוספת תג
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