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Label-free, direct localization and relative quantitation of the RNA nucleobase methylations m(6)A, m(5)C, m(3)U, and m(5)U by top-down mass spectrometry

Nucleobase methylations are ubiquitous posttranscriptional modifications of ribonucleic acids (RNA) that can substantially increase the structural diversity of RNA in a highly dynamic fashion with implications for gene expression and human disease. However, high throughput, deep sequencing does not...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Glasner, Heidelinde, Riml, Christian, Micura, Ronald, Breuker, Kathrin
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
Fag:
RNA
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570050/
https://ncbi.nlm.nih.gov/pubmed/28549193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx470
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