Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility

Dietary excess triggers accumulation of pro-inflammatory microglia in the mediobasal hypothalamus (MBH), but the components of this microgliosis and its metabolic consequences remain uncertain. Here, we show that microglial inflammatory signaling determines the immunologic response of the MBH to die...

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Vydáno v:Cell Metab
Hlavní autoři: Valdearcos, Martin, Douglass, John D., Robblee, Megan M., Dorfman, Mauricio D., Stifler, Daniel R., Bennett, Mariko L., Gerritse, Irene, Fasnacht, Rachael, Barres, Ben A., Thaler, Joshua P., Koliwad, Suneil K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5569901/
https://ncbi.nlm.nih.gov/pubmed/28683286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.05.015
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