Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice

Female mice are less susceptible to the negative metabolic consequences of high-fat diet feeding than male mice, for reasons that are incompletely understood. Here we identify sex-specific differences in hypothalamic microglial activation via the CX3CL1-CX3CR1 pathway that mediate the resistance of...

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Publicado no:Nat Commun
Main Authors: Dorfman, Mauricio D., Krull, Jordan E., Douglass, John D., Fasnacht, Rachael, Lara-Lince, Fernando, Meek, Thomas H., Shi, Xiaogang, Damian, Vincent, Nguyen, Hong T., Matsen, Miles E., Morton, Gregory J., Thaler, Joshua P.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5322503/
https://ncbi.nlm.nih.gov/pubmed/28223698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14556
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