Inhibition of T-cell receptor beta-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck.

Eitemau Tebyg

• Decreased signaling competence as a result of receptor overexpression: overexpression of CD4 reduces its ability to activate p56lck tyrosine kinase and to regulate T-cell antigen receptor expression in immature CD4+CD8+ thymocytes.
  gan: Nakayama, T, et al.
  Cyhoeddwyd: (1993)
• Association of p56lck with IL-2 receptor beta chain is critical for the IL-2-induced activation of p56lck.
  gan: Minami, Y, et al.
  Cyhoeddwyd: (1993)
• Thymic tumorigenesis induced by overexpression of p56lck.
  gan: Abraham, K M, et al.
  Cyhoeddwyd: (1991)
• Structural requirements for enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck.
  gan: Caron, L, et al.
  Cyhoeddwyd: (1992)
• CD5 acts as a tyrosine kinase substrate within a receptor complex comprising T-cell receptor zeta chain/CD3 and protein-tyrosine kinases p56lck and p59fyn.
  gan: Burgess, K E, et al.
  Cyhoeddwyd: (1992)