Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor.

The extracellular protease urokinase is known to be crucially involved in morphogenesis, tissue repair and tumor invasion by mediating matrix degradation and cell migration. Hepatocyte growth factor/scatter factor (HGF/SF) is a secretory product of stromal fibroblasts, sharing structural motifs with...

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Veröffentlicht in:EMBO J
Hauptverfasser: Naldini, L, Tamagnone, L, Vigna, E, Sachs, M, Hartmann, G, Birchmeier, W, Daikuhara, Y, Tsubouchi, H, Blasi, F, Comoglio, P M
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 1992
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC556958/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1334458/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1992.tb05588.x
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