Polymer Structure and Conformation Alter the Antigenicity of Virus-like Particle–Polymer Conjugates

Covalent conjugation of water-soluble polymers to proteins is critical for evading immune surveillance in the field of biopharmaceuticals. The most common and long-standing polymer modification is the attachment of methoxypoly(ethylene glycol) (mPEG), termed PEGylation, which has led to several clin...

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Udgivet i:J Am Chem Soc
Main Authors: Lee, Parker W., Isarov, Sergey A., Wallat, Jaqueline D., Molugu, Sudheer K., Shukla, Sourabh, Sun, Jessie E. P., Zhang, Jun, Zheng, Yi, Dougherty, Melissa Lucius, Konkolewicz, Dominik, Stewart, Phoebe L., Steinmetz, Nicole F., Hore, Michael J. A., Pokorski, Jonathan K.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5569573/
https://ncbi.nlm.nih.gov/pubmed/28121424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b11643
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