Polymer Structure and Conformation Alter the Antigenicity of Virus-like Particle–Polymer Conjugates

Covalent conjugation of water-soluble polymers to proteins is critical for evading immune surveillance in the field of biopharmaceuticals. The most common and long-standing polymer modification is the attachment of methoxypoly(ethylene glycol) (mPEG), termed PEGylation, which has led to several clin...

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Publicat a:J Am Chem Soc
Autors principals: Lee, Parker W., Isarov, Sergey A., Wallat, Jaqueline D., Molugu, Sudheer K., Shukla, Sourabh, Sun, Jessie E. P., Zhang, Jun, Zheng, Yi, Dougherty, Melissa Lucius, Konkolewicz, Dominik, Stewart, Phoebe L., Steinmetz, Nicole F., Hore, Michael J. A., Pokorski, Jonathan K.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5569573/
https://ncbi.nlm.nih.gov/pubmed/28121424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b11643
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