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Assessing the interplay between the physicochemical parameters of ion-pairing reagents and the analyte sequence on the electrospray desorption process for oligonucleotides

Alkylamines are widely used as ion-pairing agents during LC-MS of oligonucleotides. In addition to a better chromatographic separation, they also assist with the desorption of oligonucleotide ions into the gas phase, cause charge state reduction and decrease cation adduction. However, the choice of...

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Bibliographic Details
Published in:J Am Soc Mass Spectrom
Main Authors: Basiri, Babak, Murph, Mandi M., Bartlett, Michael G.
Format: Artigo
Language:Inglês
Published: 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5569388/
https://ncbi.nlm.nih.gov/pubmed/28405940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13361-017-1671-6
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