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Analytical and preparative separation of phosphorothioated oligonucleotides: columns and ion-pair reagents
Oligonucleotide drugs represent an emerging area in the pharmaceutical industry. Solid-phase synthesis generates many structurally closely related impurities, making efficient separation systems for purification and analysis a key challenge during pharmaceutical drug development. To increase the fun...
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| Publicado en: | Anal Bioanal Chem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Springer Berlin Heidelberg
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6992550/ https://ncbi.nlm.nih.gov/pubmed/31814048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00216-019-02236-9 |
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