Analytical and preparative separation of phosphorothioated oligonucleotides: columns and ion-pair reagents

Oligonucleotide drugs represent an emerging area in the pharmaceutical industry. Solid-phase synthesis generates many structurally closely related impurities, making efficient separation systems for purification and analysis a key challenge during pharmaceutical drug development. To increase the fun...

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Udgivet i:Anal Bioanal Chem
Main Authors: Enmark, Martin, Bagge, Joakim, Samuelsson, Jörgen, Thunberg, Linda, Örnskov, Eivor, Leek, Hanna, Limé, Fredrik, Fornstedt, Torgny
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2019
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6992550/
https://ncbi.nlm.nih.gov/pubmed/31814048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00216-019-02236-9
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