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Oncogenic v-Abl tyrosine kinase can inhibit or stimulate growth, depending on the cell context.

The v-abl oncogene of Abelson murine leukemia virus (A-MuLV) induces two opposite phenotypes in NIH3T3 cells. In the majority of cells, v-abl causes a growth arrest at the G1 phase of the cell cycle; while in a minority of cells, v-abl abrogates the requirement for growth factors. Using temperature...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:EMBO J
Main Authors: Renshaw, M W, Kipreos, E T, Albrecht, M R, Wang, J Y
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 1992
Teme:
Online dostop:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC556905/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1396587/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1992.tb05488.x
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