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Distinct dynamics and interaction patterns in H- and K-Ras oncogenic P-loop mutants
Despite years of study the structural or dynamical basis for the differential reactivity and oncogenicity of Ras isoforms and mutants remains unclear. In this study, we investigated the effects of amino acid variations on the structure and dynamics of wild type and oncogenic mutants G12D, G12V and G...
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| Udgivet i: | Proteins |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5568977/ https://ncbi.nlm.nih.gov/pubmed/28498561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.25317 |
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