Donor pulmonary intravascular nonclassical monocytes recruit recipient neutrophils and mediate primary lung allograft dysfunction

Primary graft dysfunction is the predominant driver of mortality and graft loss after lung transplantation. Recruitment of neutrophils as a result of ischemia-reperfusion injury is thought to cause primary graft dysfunction; however, the mechanisms that regulate neutrophil influx into the injured lu...

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Udgivet i:Sci Transl Med
Main Authors: Zheng, Zhikun, Chiu, Stephen, Akbarpour, Mahzad, Sun, Haiying, Reyfman, Paul A., Anekalla, Kishore R., Abdala-Valencia, Hiam, Edgren, Daphne, Li, Wenjun, Kreisel, Daniel, Korobova, Farida V., Fernandez, Ramiro, McQuattie-Pimentel, Alexandra, Zhang, Zheng J., Perlman, Harris, Misharin, Alexander V., Scott Budinger, GR, Bharat, Ankit
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568853/
https://ncbi.nlm.nih.gov/pubmed/28615357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aal4508
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