Inducible CCR2+ nonclassical monocytes mediate the regression of cancer metastasis

A major limitation of immunotherapy is the development of resistance resulting from cancer-mediated inhibition of host lymphocytes. Cancer cells release CCL2 to recruit classical monocytes expressing its receptor CCR2 for the promotion of metastasis and resistance to immunosurveillance. In the circu...

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Hlavní autoři: Xianpeng Liu, Ziyou Ren, Can Tan, Félix L. Núñez-Santana, Megan E. Kelly, Yuanqing Yan, Haiying Sun, Hiam Abdala-Valencia, Wenbin Yang, Qiang Wu, Takahide Toyoda, Marija Milisav, S. Marina Casalino-Matsuda, Emilia Lecuona, Emily Jeong Cerier, Lena J. Heung, Mohamed E. Abazeed, Harris Perlman, Ruli Gao, Navdeep S. Chandel, G.R. Scott Budinger, Ankit Bharat
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2024-11-01
Edice:The Journal of Clinical Investigation
Témata:
Immunology
On-line přístup:https://doi.org/10.1172/JCI179527
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