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Neurotoxic mechanisms of paclitaxel are local to the distal axon and independent of transport defects
Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting side effect of paclitaxel and other chemotherapeutic agents. Paclitaxel binds and stabilizes microtubules, but the cellular mechanisms that underlie paclitaxel’s neurotoxic effects are not well understood. We therefore used primary...
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| Publicado no: | Exp Neurol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5568627/ https://ncbi.nlm.nih.gov/pubmed/27894788 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2016.11.015 |
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