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Neurotoxic mechanisms of paclitaxel are local to the distal axon and independent of transport defects

Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting side effect of paclitaxel and other chemotherapeutic agents. Paclitaxel binds and stabilizes microtubules, but the cellular mechanisms that underlie paclitaxel’s neurotoxic effects are not well understood. We therefore used primary...

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Bibliografiske detaljer
Udgivet i:Exp Neurol
Main Authors: Gornstein, Erica L., Schwarz, Thomas L.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568627/
https://ncbi.nlm.nih.gov/pubmed/27894788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2016.11.015
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