The Cardiomyopathy-Associated K15N Mutation in Tropomyosin Alters Actin Filament Pointed End Dynamics

Correct assembly of thin filaments composed of actin and actin-binding proteins is of crucial importance for properly functioning muscle cells. Tropomyosin (Tpm) mediates the binding of tropomodulin (Tmod) and leiomodin (Lmod) at the slow-growing, or pointed, ends of the thin filaments. Together the...

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Bibliographic Details
Published in:Arch Biochem Biophys
Main Authors: Colpan, Mert, Ly, Thu, Grover, Samantha, Tolkatchev, Dmitri, Kostyukova, Alla S.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568491/
https://ncbi.nlm.nih.gov/pubmed/28732641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2017.07.006
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