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HPN-07, a free radical spin trapping agent, protects against functional, cellular and electrophysiological changes in the cochlea induced by acute acoustic trauma

Oxidative stress is considered a major cause of the structural and functional changes associated with auditory pathologies induced by exposure to acute acoustic trauma AAT). In the present study, we examined the otoprotective effects of 2,4-disulfophenyl-N-tert-butylnitrone (HPN-07), a nitrone-based...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ewert, Donald, Hu, Ning, Du, Xiaoping, Li, Wei, West, Matthew B., Choi, Chul-Hee, Floyd, Robert, Kopke, Richard D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568441/
https://ncbi.nlm.nih.gov/pubmed/28832600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0183089
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