IL-18 associated with lung lymphoid aggregates drives IFNγ production in severe COPD

BACKGROUND: Increased interferon gamma (IFNγ) release occurs in Chronic Obstructive Pulmonary Disease (COPD) lungs. IFNγ supports optimal viral clearance, but if dysregulated could increase lung tissue destruction. METHODS: The present study investigates which mediators most closely correlate with I...

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Dettagli Bibliografici
Pubblicato in:Respir Res
Autori principali: Briend, Emmanuel, Ferguson, G. John, Mori, Michiko, Damera, Gautam, Stephenson, Katherine, Karp, Natasha A., Sethi, Sanjay, Ward, Christine K., Sleeman, Matthew A., Erjefält, Jonas S., Finch, Donna K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568255/
https://ncbi.nlm.nih.gov/pubmed/28830544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-017-0641-7
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