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A novel antifolate resistance gene on the amplified H circle of Leishmania.

In several Leishmania spp., resistance to methotrexate and other drugs is often associated with amplification of the chromosomal H region in the form of extrachromosomal H circles. We report here that the H circle of Leishmania tarentolae contains an 867 bp open reading frame, ltdh, which mediates h...

詳細記述

保存先:
書誌詳細
出版年:EMBO J
主要な著者: Papadopoulou, B, Roy, G, Ouellette, M
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 1992
主題:
オンライン・アクセス:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC556819/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1396560/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1992.tb05444.x
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