Tetanus toxin is a zinc protein and its inhibition of neurotransmitter release and protease activity depend on zinc.

Tetanus and botulinum neurotoxins are the most potent toxins known. They bind to nerve cells, penetrate the cytosol and block neurotransmitter release. Comparison of their predicted amino acid sequences reveals a highly conserved segment that contains the HexxH zinc binding motif of metalloendopepti...

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Bibliographische Detailangaben
Veröffentlicht in:EMBO J
Hauptverfasser: Schiavo, G, Poulain, B, Rossetto, O, Benfenati, F, Tauc, L, Montecucco, C
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 1992
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC556816/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1396558/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1992.tb05441.x
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