BHX, a novel pyrazoline derivative, inhibits breast cancer cell invasion by reversing the epithelial-mesenchymal transition and down-regulating Wnt/β-catenin signalling

The novel pyrazoline derivative, BHX, has recently been shown to exhibit potent anti-tumour activity by blocking the Wnt/β-catenin signalling pathway. However, its effect on breast cancer growth and invasion are unknown. Our results show that BHX suppresses MDA-MB-231 cell viability and colony forma...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Bao, Hanmei, Zhang, Qing, Zhu, Zhongling, Xu, Hui, Ding, Fengxia, Wang, Meisa, Du, Shuangshuang, Du, Yibo, Yan, Zhao
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567253/
https://ncbi.nlm.nih.gov/pubmed/28831201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09655-7
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