BHX Inhibits the Wnt Signaling Pathway by Suppressing β-catenin Transcription in the Nucleus

BHX (N-(4-hydroxybenzyl)-1,3,4-triphenyl-4,5-dihydro-1H-pyrazole-5-carboxamide), a Wnt signaling pathway inhibitor, effectively inhibits tumor cell growth, but the underlying mechanism is unclear. Thus, we aim to investigate the effects and associated mechanism of BHX action on A549 and MCF-7 cell l...

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Publicado en:Sci Rep
Autores principales: Ding, Fengxia, Wang, Meisa, Du, Yibo, Du, Shuangshuang, Zhu, Zhongling, Yan, Zhao
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133598/
https://ncbi.nlm.nih.gov/pubmed/27910912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep38331
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