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Reversible inactivation of a peptidoglycan transpeptidase by a β-lactam antibiotic mediated by β-lactam-ring recyclization in the enzyme active site

β-lactam antibiotics act as suicide substrates of transpeptidases responsible for the last cross-linking step of peptidoglycan synthesis in the bacterial cell wall. Nucleophilic attack of the β-lactam carbonyl by the catalytic residue (Ser or Cys) of transpeptidases results in the opening of the β-l...

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Publicat a:Sci Rep
Autors principals: Edoo, Zainab, Arthur, Michel, Hugonnet, Jean-Emmanuel
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567249/
https://ncbi.nlm.nih.gov/pubmed/28831100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09341-8
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